Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5
نویسندگان
چکیده
منابع مشابه
Nanosized Technological Approaches for the Delivery of Poorly Water Soluble Drugs
A major hurdle in pharmaceutical formulation is water insolubility of most of drugs affecting their stability and bioavailability. If the drug is also insoluble in organic medium, it is difficult to deliver it in a sufficiently bioavailable form and hence it is a great challenge to formulation researchers to overcome such difficulty. Although some approaches are available for enhancing th...
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Lipospheres are a drug encapsulation system composed of water dispersible solid microparticles of particle size between 0.01 and 100 μm in diameter with a solid hydrophobic lipid core stabilized by a layer of phospholipid molecules embedded in their surface. The bioactive compound is dissolved or dispersed in the solid lipid matrix of the internal core. Since lipospheres were introduced in the ...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2016
ISSN: 0169-409X
DOI: 10.1016/j.addr.2016.04.022